Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis

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Class IA phosphoinositide 3-kinase (PI3K) galvanizes fundamental cellular processes such as migration, proliferation, and differentiation. To enable multifaceted roles, the catalytic subunit p110 utilizes a multidomain, regulatory subunit p85 through its inter SH2 domain (iSH2). In cell migration, t...

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Detalles Bibliográficos
Autores principales: Matsubayashi, Hideaki T., Mountain, Jack, Yao, Tony, Peterson, Amy F., Deb Roy, Abhijit, Inoue, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881872/
https://www.ncbi.nlm.nih.gov/pubmed/36712134
http://dx.doi.org/10.1101/2022.12.31.522383
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