Additive energetic contributions of multiple peptide positions determine the relative promiscuity of viral and human sequences for PDZ domain targets

Protein-protein interactions that include recognition of short sequences of amino acids, or peptides, are critical in cellular processes. Protein-peptide interaction surface areas are relatively small and shallow, and there are often overlapping specificities in families of peptide-binding domains....

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Detalles Bibliográficos
Autores principales: Tahti, Elise F., Blount, Jadon M., Jackson, Sophie N., Gao, Melody, Gill, Nicholas P., Smith, Sarah N., Pederson, Nick J., Rumph, Simone N., Struyvenberg, Sarah A., Mackley, Iain G. P., Madden, Dean R., Amacher, Jeanine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881875/
https://www.ncbi.nlm.nih.gov/pubmed/36711692
http://dx.doi.org/10.1101/2022.12.31.522388

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