Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform

Genetic interactions mediate the emergence of phenotype from genotype, but initial technologies for combinatorial genetic perturbation in mammalian cells suffer from inefficiency and are challenging to scale. Recent focus on paralog synthetic lethality in cancer cells offers an opportunity to evalua...

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Detalles Bibliográficos
Autores principales: Anvar, Nazanin Esmaeili, Lin, Chenchu, Ma, Xingdi, Wilson, Lori L., Steger, Ryan, Sangree, Annabel K., Colic, Medina, Wang, Sidney H., Doench, John G., Hart, Traver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881895/
https://www.ncbi.nlm.nih.gov/pubmed/36712129
http://dx.doi.org/10.1101/2023.01.03.522655

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