Systematic elucidation of genetic mechanisms underlying cholesterol uptake

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Genetic variation contributes greatly to LDL cholesterol (LDL-C) levels and coronary artery disease risk. By combining analysis of rare coding variants from the UK Biobank and genome-scale CRISPR-Cas9 knockout and activation screening, we have substantially improved the identification of genes whose...

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Detalles Bibliográficos
Autores principales: Hamilton, Marisa C., Fife, James D., Akinci, Ersin, Yu, Tian, Khowpinitchai, Benyapa, Cha, Minsun, Barkal, Sammy, Thi, Thi Tun, Yeo, Grace H.T., Ramos Barroso, Juan Pablo, Jake Francoeur, Matthew, Velimirovic, Minja, Gifford, David K., Lettre, Guillaume, Yu, Haojie, Cassa, Christopher A., Sherwood, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881906/
https://www.ncbi.nlm.nih.gov/pubmed/36711952
http://dx.doi.org/10.1101/2023.01.09.500804
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