Cargando…

MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion

Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5’-cap binding protein, eukaryotic translation initiation factor (eIF) 4E. These kinases are downstream...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shiers, Stephanie, Sahn, James J., Price, Theodore J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881964/ https://www.ncbi.nlm.nih.gov/pubmed/36711529 http://dx.doi.org/10.1101/2023.01.04.522773

Ejemplares similares

MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways
por: Moore, C. E. J., et al.
Publicado: (2016)

MNK inhibitor eFT508 (Tomivosertib) suppresses ectopic activity in human dorsal root ganglion neurons from dermatomes with radicular neuropathic pain
por: Li, Yan, et al.
Publicado: (2023)

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma
por: Ke, Xin-Yu, et al.
Publicado: (2021)

Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer
por: Pinto-Díez, Celia, et al.
Publicado: (2018)

MNK Proteins as Therapeutic Targets in Leukemia
por: Mazewski, Candice, et al.
Publicado: (2023)

Role of MAPK/MNK1 signaling in virus replication
por: Kumar, Ram, et al.
Publicado: (2018)

Oncogenic MNK signalling regulates the metastasis suppressor NDRG1
por: Tian, Shuye, et al.
Publicado: (2017)

Small Molecules Targeting the Inactive Form of the Mnk1/2 Kinases
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2017)

Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors
por: Sansook, Supojjanee, et al.
Publicado: (2018)

Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor
por: Bou-Petit, Elisabeth, et al.
Publicado: (2022)

A role for pre-mNK cells in tumor progression
por: Rosinsky, Carolyn, et al.
Publicado: (2016)

An Aptamer against MNK1 for Non-Small Cell Lung Cancer Treatment
por: Carrión-Marchante, Rebeca, et al.
Publicado: (2023)

Revisiting the Prominent Anti-Tumoral Potential of Pre-mNK Cells
por: Guimont-Desrochers, Fanny, et al.
Publicado: (2013)

Controlling TIME: How MNK Kinases Function to Shape Tumor Immunity
por: Pham, Thao N.D., et al.
Publicado: (2020)

MNK2 deficiency potentiates β-cell regeneration via translational regulation
por: Karampelias, Christos, et al.
Publicado: (2022)

Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway
por: Moreau, Maïté M., et al.
Publicado: (2022)

The MNK1/2-eIF4E Axis as a Potential Therapeutic Target in Melanoma
por: Prabhu, Sathyen A., et al.
Publicado: (2020)

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells
por: Li, Peng, et al.
Publicado: (2016)

Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction
por: Franco-Enzástiga, Úrzula, et al.
Publicado: (2023)

The Molecular Fingerprint of Dorsal Root and Trigeminal Ganglion Neurons
por: Lopes, Douglas M., et al.
Publicado: (2017)

Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion
por: Mun, Se Hwan, et al.
Publicado: (2021)

First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug
por: Teneggi, Vincenzo, et al.
Publicado: (2019)

MAP kinase-interacting kinase 1 (MNK1) plays as a tumor suppressor in bladder cancer
por: Chen, Zhuangfei, et al.
Publicado: (2020)

Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity
por: Sandeman, Lauren Y., et al.
Publicado: (2020)

LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration
por: Zhang, Shiqing, et al.
Publicado: (2015)

MNK as a potential pharmacological target for suppressing LPS-induced acute lung injury in mice
por: Gao, Jianfeng, et al.
Publicado: (2021)

The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
por: Ramalingam, Senthilmurugan, et al.
Publicado: (2019)

Phosphorylated Mnk1 and eIF4E Are Associated with Lymph Node Metastasis and Poor Prognosis of Nasopharyngeal Carcinoma
por: Zheng, Jun, et al.
Publicado: (2014)

Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells
por: García-Recio, Eva M, et al.
Publicado: (2016)

Bilirubin Restrains the Anticancer Effect of Vemurafenib on BRAF-Mutant Melanoma Cells Through ERK-MNK1 Signaling
por: Tan, Yufan, et al.
Publicado: (2021)

An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer
por: Pinto-Díez, C., et al.
Publicado: (2022)

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells
por: Eckerdt, Frank, et al.
Publicado: (2014)

Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening
por: Jin, Xin, et al.
Publicado: (2022)

Infection by the Protozoan Parasite Toxoplasma gondii Inhibits Host MNK1/2-eIF4E Axis to Promote Its Survival
por: Leroux, Louis-Philippe, et al.
Publicado: (2020)

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

Design, Synthesis and Bioactivity Evaluation of 4,6-Disubstituted Pyrido[3,2-d]pyrimidine Derivatives as Mnk and HDAC Inhibitors
por: Xing, Kun, et al.
Publicado: (2020)

Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy
por: Li, Zhiqiang, et al.
Publicado: (2016)

Circadian activities of the brain MNK‐eIF4E signalling axis contribute to diurnal rhythms of some cognitive functions
por: Liu, Dong, et al.
Publicado: (2022)

Inhibition of Growth of TSC2-Null Cells by a PI3K/mTOR Inhibitor but Not by a Selective MNK1/2 Inhibitor
por: Evans, Jilly F., et al.
Publicado: (2019)

RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing
por: Arendt-Tranholm, Asta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m6u4a7sg6bq52av0kphp8lf8ca