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Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring

Longitudinal radiological monitoring of biomedical devices is increasingly important, driven by risk of device failure following implantation. Polymeric devices are poorly visualized with clinical imaging, hampering efforts to use diagnostic imaging to predict failure and enable intervention. Introd...

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Autores principales: Pawelec, Kendell M, Tu, Ethan, Chakravarty, Shatadru, Hix, Jeremy ML, Buchanan, Lane, Kenney, Legend, Buchanan, Foster, Chatterjee, Nandini, Das, Subhashri, Alessio, Adam, Shapiro, Erik M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881976/
https://www.ncbi.nlm.nih.gov/pubmed/36711467
http://dx.doi.org/10.1101/2023.01.06.523025
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author Pawelec, Kendell M
Tu, Ethan
Chakravarty, Shatadru
Hix, Jeremy ML
Buchanan, Lane
Kenney, Legend
Buchanan, Foster
Chatterjee, Nandini
Das, Subhashri
Alessio, Adam
Shapiro, Erik M
author_facet Pawelec, Kendell M
Tu, Ethan
Chakravarty, Shatadru
Hix, Jeremy ML
Buchanan, Lane
Kenney, Legend
Buchanan, Foster
Chatterjee, Nandini
Das, Subhashri
Alessio, Adam
Shapiro, Erik M
author_sort Pawelec, Kendell M
collection PubMed
description Longitudinal radiological monitoring of biomedical devices is increasingly important, driven by risk of device failure following implantation. Polymeric devices are poorly visualized with clinical imaging, hampering efforts to use diagnostic imaging to predict failure and enable intervention. Introducing nanoparticle contrast agents into polymers is a potential method for creating radiopaque materials that can be monitored via computed tomography. However, properties of composites may be altered with nanoparticle addition, jeopardizing device functionality. This, we investigated material and biomechanical response of model nanoparticle-doped biomedical devices (phantoms), created from 0–40wt% TaO(x) nanoparticles in polycaprolactone, poly(lactide-co-glycolide) 85:15 and 50:50, representing non-, slow and fast degrading systems, respectively. Phantoms degraded over 20 weeks in vitro, in simulated physiological environments: healthy tissue (pH 7.4), inflammation (pH 6.5), and lysosomal conditions (pH 5.5), while radiopacity, structural stability, mechanical strength and mass loss were monitored. The polymer matrix determined overall degradation kinetics, which increased with lower pH and higher TaO(x) content. Importantly, all radiopaque phantoms could be monitored for a full 20-weeks. Phantoms implanted in vivo and serially imaged, demonstrated similar results. An optimal range of 5–20wt% TaO(x) nanoparticles balanced radiopacity requirements with implant properties, facilitating next-generation biomedical devices.
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spelling pubmed-98819762023-01-28 Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring Pawelec, Kendell M Tu, Ethan Chakravarty, Shatadru Hix, Jeremy ML Buchanan, Lane Kenney, Legend Buchanan, Foster Chatterjee, Nandini Das, Subhashri Alessio, Adam Shapiro, Erik M bioRxiv Article Longitudinal radiological monitoring of biomedical devices is increasingly important, driven by risk of device failure following implantation. Polymeric devices are poorly visualized with clinical imaging, hampering efforts to use diagnostic imaging to predict failure and enable intervention. Introducing nanoparticle contrast agents into polymers is a potential method for creating radiopaque materials that can be monitored via computed tomography. However, properties of composites may be altered with nanoparticle addition, jeopardizing device functionality. This, we investigated material and biomechanical response of model nanoparticle-doped biomedical devices (phantoms), created from 0–40wt% TaO(x) nanoparticles in polycaprolactone, poly(lactide-co-glycolide) 85:15 and 50:50, representing non-, slow and fast degrading systems, respectively. Phantoms degraded over 20 weeks in vitro, in simulated physiological environments: healthy tissue (pH 7.4), inflammation (pH 6.5), and lysosomal conditions (pH 5.5), while radiopacity, structural stability, mechanical strength and mass loss were monitored. The polymer matrix determined overall degradation kinetics, which increased with lower pH and higher TaO(x) content. Importantly, all radiopaque phantoms could be monitored for a full 20-weeks. Phantoms implanted in vivo and serially imaged, demonstrated similar results. An optimal range of 5–20wt% TaO(x) nanoparticles balanced radiopacity requirements with implant properties, facilitating next-generation biomedical devices. Cold Spring Harbor Laboratory 2023-01-08 /pmc/articles/PMC9881976/ /pubmed/36711467 http://dx.doi.org/10.1101/2023.01.06.523025 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Pawelec, Kendell M
Tu, Ethan
Chakravarty, Shatadru
Hix, Jeremy ML
Buchanan, Lane
Kenney, Legend
Buchanan, Foster
Chatterjee, Nandini
Das, Subhashri
Alessio, Adam
Shapiro, Erik M
Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring
title Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring
title_full Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring
title_fullStr Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring
title_full_unstemmed Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring
title_short Incorporating Radiopacity into Implantable Polymeric Biomedical Devices for Clinical Radiological Monitoring
title_sort incorporating radiopacity into implantable polymeric biomedical devices for clinical radiological monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881976/
https://www.ncbi.nlm.nih.gov/pubmed/36711467
http://dx.doi.org/10.1101/2023.01.06.523025
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