Leveraging family data to design Mendelian Randomization that is provably robust to population stratification

Mendelian Randomization (MR) has emerged as a powerful approach to leverage genetic instruments to infer causality between pairs of traits in observational studies. However, the results of such studies are susceptible to biases due to weak instruments as well as the confounding effects of population...

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Detalles Bibliográficos
Autores principales: LaPierre, Nathan, Fu, Boyang, Turnbull, Steven, Eskin, Eleazar, Sankararaman, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881984/
https://www.ncbi.nlm.nih.gov/pubmed/36711635
http://dx.doi.org/10.1101/2023.01.05.522936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881984/
https://www.ncbi.nlm.nih.gov/pubmed/36711635
http://dx.doi.org/10.1101/2023.01.05.522936

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