Subclonal somatic copy number alterations emerge and dominate in recurrent osteosarcoma

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Multiple large-scale tumor genomic profiling efforts have been undertaken in osteosarcoma, however, little is known about the spatial and temporal intratumor heterogeneity and how it may drive treatment resistance. We performed whole-genome sequencing of 37 tumor samples from eight patients with rel...

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Detalles Bibliográficos
Autores principales: Kinnaman, Michael D., Zaccaria, Simone, Makohon-Moore, Alvin, Arnold, Brian, Levine, Max, Gundem, Gunes, Ossa, Juan E. Arango, Glodzik, Dominik, Rodríguez-Sánchez, M. Irene, Bouvier, Nancy, Li, Shanita, Stockfisch, Emily, Dunigan, Marisa, Cobbs, Cassidy, Bhanot, Umesh, You, Daoqi, Mullen, Katelyn, Melchor, Jerry, Ortiz, Michael V., O’Donohue, Tara, Slotkin, Emily, Wexler, Leonard H., Dela Cruz, Filemon S., Hameed, Meera, Glade Bender, Julia L., Tap, William D., Meyers, Paul A., Papaemmanuil, Elli, Kung, Andrew L., Iacobuzio-Donahue, Christine A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881990/
https://www.ncbi.nlm.nih.gov/pubmed/36711976
http://dx.doi.org/10.1101/2023.01.05.522765

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