Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

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RNA-binding proteins (RBPs) are key post-transcriptional regulators of gene expression, and thus underlie many important biological processes. Here, we developed a strategy that entails extracting a “hotspot pharmacophore” from the structure of a protein-RNA complex, to create a template for designi...

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Detalles Bibliográficos
Autores principales: Bai, Nan, Adeshina, Yusuf, Bychkov, Igor, Xia, Yan, Gowthaman, Ragul, Miller, Sven A., Gupta, Abhishek K., Johnson, David K., Lan, Lan, Golemis, Erica A., Makhov, Petr B., Xu, Liang, Pillai, Manoj M., Boumber, Yanis, Karanicolas, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882015/
https://www.ncbi.nlm.nih.gov/pubmed/36711508
http://dx.doi.org/10.1101/2023.01.09.523326
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