Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells

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Clostridioides difficile (C. diff.) is a bacterium that causes severe diarrhea and inflammation of the colon. The pathogenicity of C. diff. infection is derived from two major toxins, toxins A (TcdA) and B (TcdB). Peptide inhibitors that can be delivered to the gut to inactivate these toxins are an...

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Autores principales: Sarma, Sudeep, Catella, Carly M., Pedro, Ellyce T. San, Xiao, Xingqing, Durmusoglu, Deniz, Menegatti, Stefano, Crook, Nathan, Magness, Scott T., Hall, Carol K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882058/
https://www.ncbi.nlm.nih.gov/pubmed/36711911
http://dx.doi.org/10.1101/2023.01.10.523493

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