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Spatial transcriptomics analysis of neoadjuvant cabozantinib and nivolumab in advanced hepatocellular carcinoma identifies independent mechanisms of resistance and recurrence
Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients and recurrence can also occur. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882076/ https://www.ncbi.nlm.nih.gov/pubmed/36712023 http://dx.doi.org/10.1101/2023.01.10.523481 |
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por Zhang, Shuming, Yuan, Long, Danilova, Ludmila, Mo, Guanglan, Zhu, Qingfeng, Deshpande, Atul, Bell, Alexander T. F., Elisseeff, Jennifer, Popel, Aleksander S., Anders, Robert A., Jaffee, Elizabeth M., Yarchoan, Mark, Fertig, Elana J., Kagohara, Luciane T.
Publicado 2023
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Publicado 2023
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Online
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Texto