Developmental hearing loss-induced perceptual deficits are rescued by cortical expression of GABA(B) receptors

Even transient periods of developmental hearing loss during the developmental critical period have been linked to long-lasting deficits in auditory perception, including temporal and spectral processing, which correlate with speech perception and educational attainment. In gerbils, hearing loss-induced perceptual deficits are correlated with a reduction of both ionotropic GABA(A) and metabotropic GABA(B) receptor-mediated synaptic inhibition in auditory cortex, but most research on critical period plasticity has focused on GABA(A) receptors. We developed viral vectors to express both endogenous GABA(A) or GABA(B) receptor subunits in auditory cortex and tested their capacity to restore perception of temporal and spectral auditory cues following critical period hearing loss in the Mongolian gerbil. HL significantly impaired perception of both temporal and spectral auditory cues. While both vectors similarly increased IPSCs in auditory cortex, only overexpression of GABA(B) receptors improved perceptual thresholds after HL to be similar to those of animals without developmental hearing loss. These findings identify the GABA(B) receptor as an important regulator of sensory perception in cortex and point to potential therapeutic targets for developmental sensory disorders.