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Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. We developed and validated a novel method to amplify Asyn fibrils extracted from LBD postmortem tissue samples and used solid state nucl...

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Detalles Bibliográficos
Autores principales:	Dhavale, Dhruva D., Barclay, Alexander M., Borcik, Collin G., Basore, Katherine, Gordon, Isabelle R., Liu, Jialu, Milchberg, Moses H., O’shea, Jennifer, Rau, Michael J., Smith, Zachary, Sen, Soumyo, Summers, Brock, Smith, John, Warmuth, Owen A., Chen, Qian, Fitzpatrick, James A. J., Schwieters, Charles D., Tajkhorshid, Emad, Rienstra, Chad M., Kotzbauer, Paul T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882085/ https://www.ncbi.nlm.nih.gov/pubmed/36711931 http://dx.doi.org/10.1101/2023.01.09.523303

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