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Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

Hutchinson-Gilford Progeria Syndrome results in rapid aging and severe cardiovascular sequelae that accelerate near end of life. We associate progressive deterioration of arterial structure and function with single cell transcriptional changes, which reveals a rapid disease process in proximal elast...

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Detalles Bibliográficos
Autores principales:	Murtada, Sae-Il, Kawamura, Yuki, Cavinato, Cristina, Wang, Mo, Ramachandra, Abhay B., Spronck, Bart, Tellides, George, Humphrey, Jay D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882088/ https://www.ncbi.nlm.nih.gov/pubmed/36711514 http://dx.doi.org/10.1101/2023.01.10.523266

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