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Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway
Constitutively active mutations in the Gα(i2) and Gα(oA) subunits of heterotrimeric G proteins have been identified in several human cancers including breast cancer, but their functional significance in tumorigenesis and metastasis has not been well characterized. In this study, we show that express...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882124/ https://www.ncbi.nlm.nih.gov/pubmed/36711612 http://dx.doi.org/10.1101/2023.01.16.524334 |