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Specificity Guides Interpretation: On H3K4 Methylation at Enhancers and Broad Promoters
In 2018, we used internally calibrated chromatin immunoprecipitation (ICeChIP) to find that many of the most commonly used antibodies against H3K4 methylforms had significant off-target binding, which compromised the findings of at least eight literature paradigms that used these antibodies for ChIP...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882130/ https://www.ncbi.nlm.nih.gov/pubmed/36711866 http://dx.doi.org/10.1101/2023.01.16.524067 |