Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin(2) G protein-coupled receptor

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The signaling peptides adrenomedullin 2/intermedin (AM2/IMD), adrenomedullin (AM), and CGRP have overlapping and distinct functions in the cardiovascular, lymphatic, and nervous systems by activating three shared receptors comprised of the class B GPCR CLR in complex with a RAMP1, −2, or −3 modulato...

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Detalles Bibliográficos
Autores principales: Babin, Katie M., Karim, Jordan A., Gordon, Peyton H., Lennon, James, Dickson, Alex, Pioszak, Augen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882245/
https://www.ncbi.nlm.nih.gov/pubmed/36711519
http://dx.doi.org/10.1101/2023.01.13.523955
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