Direct observation of coordinated assembly of individual native centromeric nucleosomes

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Eukaryotic chromosome segregation requires the kinetochore, a megadalton-sized machine that forms on specialized centromeric chromatin containing CENP-A, a histone H3 variant. CENP-A deposition requires a chaperone protein HJURP that targets it to the centromere, but it has remained unclear whether...

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Detalles Bibliográficos
Autores principales: Popchock, Andrew R., Larson, Joshua D., Dubrulle, Julien, Asbury, Charles L., Biggins, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882320/
https://www.ncbi.nlm.nih.gov/pubmed/36711558
http://dx.doi.org/10.1101/2023.01.20.524981

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