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Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein
Double homeobox (DUX) genes are unique to eutherian mammals and normally expressed transiently during zygotic genome activation. The canonical member, DUX4, is involved in facioscapulohumeral muscular dystrophy (FSHD) and cancer, when misexpressed in other contexts. We evaluate the 3 human DUX genes...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882399/ https://www.ncbi.nlm.nih.gov/pubmed/36711898 http://dx.doi.org/10.1101/2023.01.21.524976 |
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por Bosnakovski, Darko, Toso, Erik A., Ener, Elizabeth T., Gearhart, Micah D., Yin, Lulu, Lüttmann, Felipe F., Magli, Alessandro, Shi, Ke, Kim, Johnny, Aihara, Hideki, Kyba, Michael
Publicado 2023
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Publicado 2023
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Online
Artículo
Texto