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Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection
BACKGROUND AND OBJECTIVES: Approximately 25% of pediatric patients who undergo cerebellar tumor resection develop cerebellar mutism syndrome (CMS). Our group recently showed that damage to the cerebellar outflow pathway is associated with increased risk of CMS. Here, we tested whether these findings...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882444/ https://www.ncbi.nlm.nih.gov/pubmed/36711770 http://dx.doi.org/10.1101/2023.01.12.23284375 |
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author | Skye, Jax Bruss, Joel Toescu, Sebastian Aquilina, Kristian Lola, Gino Bardi Boes, Aaron D. |
author_facet | Skye, Jax Bruss, Joel Toescu, Sebastian Aquilina, Kristian Lola, Gino Bardi Boes, Aaron D. |
author_sort | Skye, Jax |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Approximately 25% of pediatric patients who undergo cerebellar tumor resection develop cerebellar mutism syndrome (CMS). Our group recently showed that damage to the cerebellar outflow pathway is associated with increased risk of CMS. Here, we tested whether these findings replicate in an independent cohort. METHODS: We evaluated the relationship between lesion location and the development of CMS in an observational study of 56 pediatric patients who underwent cerebellar tumor resection. We hypothesized that individuals that developed CMS after surgery (CMS+), relative to those that did not (CMS−) would have lesions that preferentially intersected with: 1) the cerebellar outflow pathway, and 2) a previously generated ‘lesion-symptom map’ of CMS. Analyses were conducted in accordance with pre-registered hypotheses and analytic methods (https://osf.io/r8yjv/). RESULTS: We found supporting evidence for both hypotheses. Compared with CMS− patients, CMS+ patients (n=10) had lesions with greater overlap with the cerebellar outflow pathway (Cohen’s d=.73, p=.05), and the CMS lesion-symptom map (Cohen’s d=1.1, p=.004). DISCUSSION: These results strengthen the association of lesion location with risk of developing CMS and demonstrate generalizability across cohorts. These findings may help to inform the optimal surgical approach to pediatric cerebellar tumors. |
format | Online Article Text |
id | pubmed-9882444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-98824442023-01-28 Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection Skye, Jax Bruss, Joel Toescu, Sebastian Aquilina, Kristian Lola, Gino Bardi Boes, Aaron D. medRxiv Article BACKGROUND AND OBJECTIVES: Approximately 25% of pediatric patients who undergo cerebellar tumor resection develop cerebellar mutism syndrome (CMS). Our group recently showed that damage to the cerebellar outflow pathway is associated with increased risk of CMS. Here, we tested whether these findings replicate in an independent cohort. METHODS: We evaluated the relationship between lesion location and the development of CMS in an observational study of 56 pediatric patients who underwent cerebellar tumor resection. We hypothesized that individuals that developed CMS after surgery (CMS+), relative to those that did not (CMS−) would have lesions that preferentially intersected with: 1) the cerebellar outflow pathway, and 2) a previously generated ‘lesion-symptom map’ of CMS. Analyses were conducted in accordance with pre-registered hypotheses and analytic methods (https://osf.io/r8yjv/). RESULTS: We found supporting evidence for both hypotheses. Compared with CMS− patients, CMS+ patients (n=10) had lesions with greater overlap with the cerebellar outflow pathway (Cohen’s d=.73, p=.05), and the CMS lesion-symptom map (Cohen’s d=1.1, p=.004). DISCUSSION: These results strengthen the association of lesion location with risk of developing CMS and demonstrate generalizability across cohorts. These findings may help to inform the optimal surgical approach to pediatric cerebellar tumors. Cold Spring Harbor Laboratory 2023-01-14 /pmc/articles/PMC9882444/ /pubmed/36711770 http://dx.doi.org/10.1101/2023.01.12.23284375 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Skye, Jax Bruss, Joel Toescu, Sebastian Aquilina, Kristian Lola, Gino Bardi Boes, Aaron D. Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
title | Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
title_full | Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
title_fullStr | Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
title_full_unstemmed | Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
title_short | Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
title_sort | investigating lesion location in relation to cerebellar mutism following pediatric tumor resection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882444/ https://www.ncbi.nlm.nih.gov/pubmed/36711770 http://dx.doi.org/10.1101/2023.01.12.23284375 |
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