A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals

Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95–95–95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95–95–95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectivel...

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Detalles Bibliográficos
Autores principales: ROSEN, Joseph G., REYNOLDS, Steven J., GALIWANGO, Ronald M., KIGOZI, Godfrey, QUINN, Thomas C., RATMANN, Oliver, NDYANABO, Anthony, NELSON, Lisa J., NAKIGOZI, Gertrude, NALUGEMWA, Margaret, RUCINSKI, Katherine B., KENNEDY, Caitlin E., CHANG, Larry W., KAGAAYI, Joseph, SERWADDA, David, GRABOWSKI, M. Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882556/
https://www.ncbi.nlm.nih.gov/pubmed/36711720
http://dx.doi.org/10.1101/2023.01.19.23284804
Descripción
Sumario:Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95–95–95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95–95–95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1,000 to <200 and <50 copies/mL. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1,000 to <200 copies/mL.

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