A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals

Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95–95–95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95–95–95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectivel...

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Autores principales: ROSEN, Joseph G., REYNOLDS, Steven J., GALIWANGO, Ronald M., KIGOZI, Godfrey, QUINN, Thomas C., RATMANN, Oliver, NDYANABO, Anthony, NELSON, Lisa J., NAKIGOZI, Gertrude, NALUGEMWA, Margaret, RUCINSKI, Katherine B., KENNEDY, Caitlin E., CHANG, Larry W., KAGAAYI, Joseph, SERWADDA, David, GRABOWSKI, M. Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882556/
https://www.ncbi.nlm.nih.gov/pubmed/36711720
http://dx.doi.org/10.1101/2023.01.19.23284804
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author ROSEN, Joseph G.
REYNOLDS, Steven J.
GALIWANGO, Ronald M.
KIGOZI, Godfrey
QUINN, Thomas C.
RATMANN, Oliver
NDYANABO, Anthony
NELSON, Lisa J.
NAKIGOZI, Gertrude
NALUGEMWA, Margaret
RUCINSKI, Katherine B.
KENNEDY, Caitlin E.
CHANG, Larry W.
KAGAAYI, Joseph
SERWADDA, David
GRABOWSKI, M. Kate
author_facet ROSEN, Joseph G.
REYNOLDS, Steven J.
GALIWANGO, Ronald M.
KIGOZI, Godfrey
QUINN, Thomas C.
RATMANN, Oliver
NDYANABO, Anthony
NELSON, Lisa J.
NAKIGOZI, Gertrude
NALUGEMWA, Margaret
RUCINSKI, Katherine B.
KENNEDY, Caitlin E.
CHANG, Larry W.
KAGAAYI, Joseph
SERWADDA, David
GRABOWSKI, M. Kate
author_sort ROSEN, Joseph G.
collection PubMed
description Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95–95–95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95–95–95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1,000 to <200 and <50 copies/mL. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1,000 to <200 copies/mL.
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spelling pubmed-98825562023-01-28 A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals ROSEN, Joseph G. REYNOLDS, Steven J. GALIWANGO, Ronald M. KIGOZI, Godfrey QUINN, Thomas C. RATMANN, Oliver NDYANABO, Anthony NELSON, Lisa J. NAKIGOZI, Gertrude NALUGEMWA, Margaret RUCINSKI, Katherine B. KENNEDY, Caitlin E. CHANG, Larry W. KAGAAYI, Joseph SERWADDA, David GRABOWSKI, M. Kate medRxiv Article Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95–95–95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95–95–95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1,000 to <200 and <50 copies/mL. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1,000 to <200 copies/mL. Cold Spring Harbor Laboratory 2023-01-20 /pmc/articles/PMC9882556/ /pubmed/36711720 http://dx.doi.org/10.1101/2023.01.19.23284804 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
ROSEN, Joseph G.
REYNOLDS, Steven J.
GALIWANGO, Ronald M.
KIGOZI, Godfrey
QUINN, Thomas C.
RATMANN, Oliver
NDYANABO, Anthony
NELSON, Lisa J.
NAKIGOZI, Gertrude
NALUGEMWA, Margaret
RUCINSKI, Katherine B.
KENNEDY, Caitlin E.
CHANG, Larry W.
KAGAAYI, Joseph
SERWADDA, David
GRABOWSKI, M. Kate
A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals
title A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals
title_full A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals
title_fullStr A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals
title_full_unstemmed A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals
title_short A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals
title_sort moving target: impacts of lowering viral load suppression cutpoints on progress towards hiv epidemic control goals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882556/
https://www.ncbi.nlm.nih.gov/pubmed/36711720
http://dx.doi.org/10.1101/2023.01.19.23284804
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