A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphoma

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There is increasing evidence that the T-cell protein, Lck, is involved in the pathogenesis of chronic lymphocytic leukemia (CLL) as well as other leukemias and lymphomas. We previously discovered that Lck binds to domain 5 of inositol 1,4,5-trisphosphate receptors (IP3R) to regulate Ca2+ homeostasis...

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Detalles Bibliográficos
Autores principales: Harr, Michael, Lavik, Andrew, McColl, Karen, Zhong, Fei, Haberer, Ben, Aldabbagh, Khadijah, Yee, Vivien, Distelhorst, Clark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882657/
https://www.ncbi.nlm.nih.gov/pubmed/36711753
http://dx.doi.org/10.21203/rs.3.rs-2436910/v1
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