The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses

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Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities. The DACH1 gene encodes a winged helix/Forkhead DNA-binding protein that competes for binding to FOXM1 sites. Herein, DACH1 gene deletion within the...

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Detalles Bibliográficos
Autores principales: Li, Zhiping, Jiao, Xuanmao, Robertson, A. Gordon, Sante, Gabriele Di, Ashton, Anthony W., DiRocco, Agnese, Wang, Min, Zhao, Jun, Addya, Sankar, Wang, Chenguang, McCue, Peter A., South, Andrew P., Cordon-Cardo, Carlos, Liu, Runzhi, Patel, Kishan, Hamid, Rasha, Parmar, Jorim, DuHadaway, James B., Jones, Steven J., Casimiro, Mathew C., Schultz, Nikolaus, Kossenkov, Andrew, Phoon, Lai Yee, Chen, Hao, Lan, Li, Sun, Yunguang, Iczkowski, Kenneth A., Rui, Hallgeir, Pestell, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882663/
https://www.ncbi.nlm.nih.gov/pubmed/36712010
http://dx.doi.org/10.21203/rs.3.rs-2423179/v1

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