B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression

Immunotherapy has revolutionized cancer treatment but has yet to be translated into brain tumors. Studies in other solid tumors suggest a central role of B-cell immunity in driving immune-checkpoint-blockade efficacy. Using single-cell and single-nuclei transcriptomics of human glioblastoma and mela...

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Detalles Bibliográficos
Autores principales: Hou, David, Castro, Brandyn, Dapash, Mark, Zolp, Andrew, Katz, Joshua, Arrieta, Víctor, Biermann, Jana, Melms, Johannes, Kueckelhaus, Jan, Benotmane, Jasim, Youngblood, Mark, Rashidi, Aida, Billingham, Leah, Dmello, Crismita, Vazquez-Cervantes, Gustavo, Lopez-Rosas, Aurora, Han, Yu, Patel, Ronit, Chia, Tzu-yi, Sun, Lu, Prins, Robert, Izar, Benjamin, Heiland, Deiter Henrik, Zhang, Peng, Sonabend, Adam, Miska, Jason, Lesniak, Maciej, Zhao, Junfei, Lee-Chang, Catalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882679/
https://www.ncbi.nlm.nih.gov/pubmed/36711497
http://dx.doi.org/10.21203/rs.3.rs-2399170/v1

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