A Machine Learning based model for a Dose Point Kernel calculation

PURPOSE: Absorbed dose calculation by kernel convolution requires the prior determination of dose point kernels (DPK). This study shows applications of machine learning to generate the DPKs for monoenergetic sources and a model to obtain DPKs for beta emitters. METHODS: DPK for monoenergetic electron sources were calculated using the FLUKA Monte Carlo (MC) code for many materials of clinical interest and initial energies ranging from 10 to 3000 keV. Three machine learning (ML) algorithms were trained using the MC DPKs. Electron monoenergetic scaled DPKs (sDPKs) were used to assess the corresponding sDPKs for beta emitters typically used in nuclear medicine, which were compared against reference published data. Finally, the ML sDPK approach was applied to a patient-specific case calculating the dose voxel kernels (DVK) for a hepatic radioembolization treatment with (90)Y. RESULTS: The three trained machine learning models demonstrated a promising capacity to predict the sDPK for both monoenergetic emissions and beta emitters of clinical interest attaining differences lower than 10% in the mean average percentage error (MAPE) as compared with previous studies. Furthermore, differences lower than 7% were obtained for the absorbed dose in patient-specific dosimetry comparing against full stochastic MC calculations. CONCLUSION: An ML model was developed to assess dosimetry calculations in nuclear medicine. The implemented approach has shown the capacity to accurately predict the sDPK for monoenergetic beta sources in a wide range of energy in different materials. The ML model to calculate the sDPK for beta-emitting radionuclides allowed to obtain VDK useful to achieve reliable patient-specific absorbed dose distributions required remarkable short computation times.