Cargando…

Staphylococcus aureus host interactions and adaptation

Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined b...

Descripción completa

Detalles Bibliográficos
Autores principales: Howden, Benjamin P., Giulieri, Stefano G., Wong Fok Lung, Tania, Baines, Sarah L., Sharkey, Liam K., Lee, Jean Y. H., Hachani, Abderrahman, Monk, Ian R., Stinear, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882747/
https://www.ncbi.nlm.nih.gov/pubmed/36707725
http://dx.doi.org/10.1038/s41579-023-00852-y
_version_ 1784879360781582336
author Howden, Benjamin P.
Giulieri, Stefano G.
Wong Fok Lung, Tania
Baines, Sarah L.
Sharkey, Liam K.
Lee, Jean Y. H.
Hachani, Abderrahman
Monk, Ian R.
Stinear, Timothy P.
author_facet Howden, Benjamin P.
Giulieri, Stefano G.
Wong Fok Lung, Tania
Baines, Sarah L.
Sharkey, Liam K.
Lee, Jean Y. H.
Hachani, Abderrahman
Monk, Ian R.
Stinear, Timothy P.
author_sort Howden, Benjamin P.
collection PubMed
description Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined by the interplay between S. aureus and host. This interplay is multidimensional and evolving, exemplified by the spread of S. aureus between humans and other animal reservoirs and the lack of success in vaccine development. In this Review, we examine recent advances in understanding the S. aureus–host interactions that lead to infections. We revisit the primary role of neutrophils in controlling infection, summarizing the discovery of new immune evasion molecules and the discovery of new functions ascribed to well-known virulence factors. We explore the intriguing intersection of bacterial and host metabolism, where crosstalk in both directions can influence immune responses and infection outcomes. This Review also assesses the surprising genomic plasticity of S. aureus, its dualism as a multi-mammalian species commensal and opportunistic pathogen and our developing understanding of the roles of other bacteria in shaping S. aureus colonization.
format Online
Article
Text
id pubmed-9882747
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-98827472023-01-30 Staphylococcus aureus host interactions and adaptation Howden, Benjamin P. Giulieri, Stefano G. Wong Fok Lung, Tania Baines, Sarah L. Sharkey, Liam K. Lee, Jean Y. H. Hachani, Abderrahman Monk, Ian R. Stinear, Timothy P. Nat Rev Microbiol Review Article Invasive Staphylococcus aureus infections are common, causing high mortality, compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an excellent case study of the potential for a bacterium to be commensal, colonizing, latent or disease-causing; these states defined by the interplay between S. aureus and host. This interplay is multidimensional and evolving, exemplified by the spread of S. aureus between humans and other animal reservoirs and the lack of success in vaccine development. In this Review, we examine recent advances in understanding the S. aureus–host interactions that lead to infections. We revisit the primary role of neutrophils in controlling infection, summarizing the discovery of new immune evasion molecules and the discovery of new functions ascribed to well-known virulence factors. We explore the intriguing intersection of bacterial and host metabolism, where crosstalk in both directions can influence immune responses and infection outcomes. This Review also assesses the surprising genomic plasticity of S. aureus, its dualism as a multi-mammalian species commensal and opportunistic pathogen and our developing understanding of the roles of other bacteria in shaping S. aureus colonization. Nature Publishing Group UK 2023-01-27 2023 /pmc/articles/PMC9882747/ /pubmed/36707725 http://dx.doi.org/10.1038/s41579-023-00852-y Text en © Springer Nature Limited 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Howden, Benjamin P.
Giulieri, Stefano G.
Wong Fok Lung, Tania
Baines, Sarah L.
Sharkey, Liam K.
Lee, Jean Y. H.
Hachani, Abderrahman
Monk, Ian R.
Stinear, Timothy P.
Staphylococcus aureus host interactions and adaptation
title Staphylococcus aureus host interactions and adaptation
title_full Staphylococcus aureus host interactions and adaptation
title_fullStr Staphylococcus aureus host interactions and adaptation
title_full_unstemmed Staphylococcus aureus host interactions and adaptation
title_short Staphylococcus aureus host interactions and adaptation
title_sort staphylococcus aureus host interactions and adaptation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882747/
https://www.ncbi.nlm.nih.gov/pubmed/36707725
http://dx.doi.org/10.1038/s41579-023-00852-y
work_keys_str_mv AT howdenbenjaminp staphylococcusaureushostinteractionsandadaptation
AT giulieristefanog staphylococcusaureushostinteractionsandadaptation
AT wongfoklungtania staphylococcusaureushostinteractionsandadaptation
AT bainessarahl staphylococcusaureushostinteractionsandadaptation
AT sharkeyliamk staphylococcusaureushostinteractionsandadaptation
AT leejeanyh staphylococcusaureushostinteractionsandadaptation
AT hachaniabderrahman staphylococcusaureushostinteractionsandadaptation
AT monkianr staphylococcusaureushostinteractionsandadaptation
AT stineartimothyp staphylococcusaureushostinteractionsandadaptation