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Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study

AIM: Primary liver cancer is usually diagnosed at advanced stages with distant metastasis, underlying the high metastatic rate and mortality in patients. This study aimed to analyse the metastatic patterns and prognosis of primary liver cancer, and its relationship with age and several other factors...

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Autores principales: Zheng, Zhaoting, Hu, Yue, Ren, Yutong, Mo, Guoheng, Wan, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882911/
https://www.ncbi.nlm.nih.gov/pubmed/36706100
http://dx.doi.org/10.1371/journal.pone.0267809
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author Zheng, Zhaoting
Hu, Yue
Ren, Yutong
Mo, Guoheng
Wan, Hao
author_facet Zheng, Zhaoting
Hu, Yue
Ren, Yutong
Mo, Guoheng
Wan, Hao
author_sort Zheng, Zhaoting
collection PubMed
description AIM: Primary liver cancer is usually diagnosed at advanced stages with distant metastasis, underlying the high metastatic rate and mortality in patients. This study aimed to analyse the metastatic patterns and prognosis of primary liver cancer, and its relationship with age and several other factors, such as histological variants, TNM stage, and grade. METHODS: We included data from 5274 patients from the Surveillance, Epidemiology, and End Results (SEER) database of the American National Cancer Institute diagnosed with primary liver cancer with metastatic disease between 2010 and 2015. The correlation between the metastatic patterns of primary liver cancer and age was evaluated. The hazard ratio (HR) and 95% confidence intervals (CI) for overall survival were calculated by applying univariate Cox analysis, while the correlation between the metastatic patterns and age was analysed by applying multivariate Cox analysis. We also plotted Kaplan-Meier curves to illustrate the correlation between overall survival (OS) and various factors. RESULTS: Several factors were associated with poorer prognosis, including age>60 years, histologic type of spindle cell variant, higher grade, no surgery, tumour size ≥ 1 cm, and lung metastasis. The rate of metastasis increased with age. Older patients (> 50 years) were prone to bone metastasis, while less likely to have lung metastasis compared with younger patients (< 50 years). Patients with lung metastasis had a higher risk of being diagnosed with metastasis in other locations. Furthermore, surgery significantly reduced mortality and primary site surgery in particular, mitigated the risk of bone and lung metastases. CONCLUSIONS: Our study shows the correlation of prognosis and metastatic patterns with age and several other factors. The findings can hopefully provide knowledge that will allow a better diagnosis and management of elderly patients with primary liver cancer.
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spelling pubmed-98829112023-01-28 Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study Zheng, Zhaoting Hu, Yue Ren, Yutong Mo, Guoheng Wan, Hao PLoS One Research Article AIM: Primary liver cancer is usually diagnosed at advanced stages with distant metastasis, underlying the high metastatic rate and mortality in patients. This study aimed to analyse the metastatic patterns and prognosis of primary liver cancer, and its relationship with age and several other factors, such as histological variants, TNM stage, and grade. METHODS: We included data from 5274 patients from the Surveillance, Epidemiology, and End Results (SEER) database of the American National Cancer Institute diagnosed with primary liver cancer with metastatic disease between 2010 and 2015. The correlation between the metastatic patterns of primary liver cancer and age was evaluated. The hazard ratio (HR) and 95% confidence intervals (CI) for overall survival were calculated by applying univariate Cox analysis, while the correlation between the metastatic patterns and age was analysed by applying multivariate Cox analysis. We also plotted Kaplan-Meier curves to illustrate the correlation between overall survival (OS) and various factors. RESULTS: Several factors were associated with poorer prognosis, including age>60 years, histologic type of spindle cell variant, higher grade, no surgery, tumour size ≥ 1 cm, and lung metastasis. The rate of metastasis increased with age. Older patients (> 50 years) were prone to bone metastasis, while less likely to have lung metastasis compared with younger patients (< 50 years). Patients with lung metastasis had a higher risk of being diagnosed with metastasis in other locations. Furthermore, surgery significantly reduced mortality and primary site surgery in particular, mitigated the risk of bone and lung metastases. CONCLUSIONS: Our study shows the correlation of prognosis and metastatic patterns with age and several other factors. The findings can hopefully provide knowledge that will allow a better diagnosis and management of elderly patients with primary liver cancer. Public Library of Science 2023-01-27 /pmc/articles/PMC9882911/ /pubmed/36706100 http://dx.doi.org/10.1371/journal.pone.0267809 Text en © 2023 Zheng et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zheng, Zhaoting
Hu, Yue
Ren, Yutong
Mo, Guoheng
Wan, Hao
Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
title Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
title_full Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
title_fullStr Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
title_full_unstemmed Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
title_short Correlation between metastatic patterns and age in patients with metastatic primary liver cancer: A population-based study
title_sort correlation between metastatic patterns and age in patients with metastatic primary liver cancer: a population-based study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882911/
https://www.ncbi.nlm.nih.gov/pubmed/36706100
http://dx.doi.org/10.1371/journal.pone.0267809
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