Lnc956-TRIM28-HSP90B1 complex on replication forks promotes CMG helicase retention to ensure stem cell genomic stability and embryogenesis

Replication stress is a major source of endogenous DNA damage. Despite the identification of numerous proteins on replication forks to modulate fork or replication machinery activities, it remains unexplored whether noncoding RNAs can localize on stalled forks and play critical regulatory roles. Her...

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Detalles Bibliográficos
Autores principales: Zhang, Weidao, Tang, Min, Wang, Lin, Zhou, Hu, Gao, Jing, Chen, Zhongliang, Zhao, Bo, Zheng, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882984/
https://www.ncbi.nlm.nih.gov/pubmed/36706191
http://dx.doi.org/10.1126/sciadv.adf6277

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