Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer

Systemic messenger RNA (mRNA) delivery to organs outside the liver, spleen, and lungs remains challenging. To overcome this issue, we hypothesized that altering nanoparticle chemistry and administration routes may enable mRNA-induced protein expression outside of the reticuloendothelial system. Here...

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Detalles Bibliográficos
Autores principales: Melamed, Jilian R., Yerneni, Saigopalakrishna S., Arral, Mariah L., LoPresti, Samuel T., Chaudhary, Namit, Sehrawat, Anuradha, Muramatsu, Hiromi, Alameh, Mohamad-Gabriel, Pardi, Norbert, Weissman, Drew, Gittes, George K., Whitehead, Kathryn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882987/
https://www.ncbi.nlm.nih.gov/pubmed/36706177
http://dx.doi.org/10.1126/sciadv.ade1444

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