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A Rare Case of Endocervical Adenocarcinoma of Gastric Type
Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into su...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882999/ https://www.ncbi.nlm.nih.gov/pubmed/36721594 http://dx.doi.org/10.7759/cureus.33059 |
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author | Mekheal, Erinie Kania, Brooke E Kapoor, Ashima Kumar, Vinod Maroules, Michael |
author_facet | Mekheal, Erinie Kania, Brooke E Kapoor, Ashima Kumar, Vinod Maroules, Michael |
author_sort | Mekheal, Erinie |
collection | PubMed |
description | Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into subtypes such as poorly differentiated versus well-differentiated (also referred to as mucinous or adenoma malignum). This cancer coined the term “gastric” subtype due to its similarity to the pancreaticobiliary and gastric tissue lining. With limited data and similar histological and genetic features of GAC, this malignancy poses a challenge for clinicians when differentiating between metastasis from the gastrointestinal tract and GAC. Here, we present a case of a 55-year-old female who presented with postmenopausal bleeding and was found to have stage IA1 endocervical adenocarcinoma of gastric subtype. The purpose of this article is to introduce a rare type of gastric adenocarcinoma with a unique site of origin in order to better understand this disease process and potentially help clinicians better diagnose and treat patients with this malignancy in the future. |
format | Online Article Text |
id | pubmed-9882999 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-98829992023-01-30 A Rare Case of Endocervical Adenocarcinoma of Gastric Type Mekheal, Erinie Kania, Brooke E Kapoor, Ashima Kumar, Vinod Maroules, Michael Cureus Internal Medicine Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into subtypes such as poorly differentiated versus well-differentiated (also referred to as mucinous or adenoma malignum). This cancer coined the term “gastric” subtype due to its similarity to the pancreaticobiliary and gastric tissue lining. With limited data and similar histological and genetic features of GAC, this malignancy poses a challenge for clinicians when differentiating between metastasis from the gastrointestinal tract and GAC. Here, we present a case of a 55-year-old female who presented with postmenopausal bleeding and was found to have stage IA1 endocervical adenocarcinoma of gastric subtype. The purpose of this article is to introduce a rare type of gastric adenocarcinoma with a unique site of origin in order to better understand this disease process and potentially help clinicians better diagnose and treat patients with this malignancy in the future. Cureus 2022-12-28 /pmc/articles/PMC9882999/ /pubmed/36721594 http://dx.doi.org/10.7759/cureus.33059 Text en Copyright © 2022, Mekheal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Mekheal, Erinie Kania, Brooke E Kapoor, Ashima Kumar, Vinod Maroules, Michael A Rare Case of Endocervical Adenocarcinoma of Gastric Type |
title | A Rare Case of Endocervical Adenocarcinoma of Gastric Type |
title_full | A Rare Case of Endocervical Adenocarcinoma of Gastric Type |
title_fullStr | A Rare Case of Endocervical Adenocarcinoma of Gastric Type |
title_full_unstemmed | A Rare Case of Endocervical Adenocarcinoma of Gastric Type |
title_short | A Rare Case of Endocervical Adenocarcinoma of Gastric Type |
title_sort | rare case of endocervical adenocarcinoma of gastric type |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882999/ https://www.ncbi.nlm.nih.gov/pubmed/36721594 http://dx.doi.org/10.7759/cureus.33059 |
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