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A Rare Case of Endocervical Adenocarcinoma of Gastric Type

Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into su...

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Detalles Bibliográficos
Autores principales: Mekheal, Erinie, Kania, Brooke E, Kapoor, Ashima, Kumar, Vinod, Maroules, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882999/
https://www.ncbi.nlm.nih.gov/pubmed/36721594
http://dx.doi.org/10.7759/cureus.33059
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author Mekheal, Erinie
Kania, Brooke E
Kapoor, Ashima
Kumar, Vinod
Maroules, Michael
author_facet Mekheal, Erinie
Kania, Brooke E
Kapoor, Ashima
Kumar, Vinod
Maroules, Michael
author_sort Mekheal, Erinie
collection PubMed
description Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into subtypes such as poorly differentiated versus well-differentiated (also referred to as mucinous or adenoma malignum). This cancer coined the term “gastric” subtype due to its similarity to the pancreaticobiliary and gastric tissue lining. With limited data and similar histological and genetic features of GAC, this malignancy poses a challenge for clinicians when differentiating between metastasis from the gastrointestinal tract and GAC. Here, we present a case of a 55-year-old female who presented with postmenopausal bleeding and was found to have stage IA1 endocervical adenocarcinoma of gastric subtype. The purpose of this article is to introduce a rare type of gastric adenocarcinoma with a unique site of origin in order to better understand this disease process and potentially help clinicians better diagnose and treat patients with this malignancy in the future.
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spelling pubmed-98829992023-01-30 A Rare Case of Endocervical Adenocarcinoma of Gastric Type Mekheal, Erinie Kania, Brooke E Kapoor, Ashima Kumar, Vinod Maroules, Michael Cureus Internal Medicine Gastric adenocarcinoma of the cervix (GAC) represents a rare mucinous endocervical cancer unrelated to human papillomavirus (HPV). GAC has been found to comprise approximately 10% of cervical adenocarcinomas internationally. As more cases have been identified, GAC has been further classified into subtypes such as poorly differentiated versus well-differentiated (also referred to as mucinous or adenoma malignum). This cancer coined the term “gastric” subtype due to its similarity to the pancreaticobiliary and gastric tissue lining. With limited data and similar histological and genetic features of GAC, this malignancy poses a challenge for clinicians when differentiating between metastasis from the gastrointestinal tract and GAC. Here, we present a case of a 55-year-old female who presented with postmenopausal bleeding and was found to have stage IA1 endocervical adenocarcinoma of gastric subtype. The purpose of this article is to introduce a rare type of gastric adenocarcinoma with a unique site of origin in order to better understand this disease process and potentially help clinicians better diagnose and treat patients with this malignancy in the future. Cureus 2022-12-28 /pmc/articles/PMC9882999/ /pubmed/36721594 http://dx.doi.org/10.7759/cureus.33059 Text en Copyright © 2022, Mekheal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Mekheal, Erinie
Kania, Brooke E
Kapoor, Ashima
Kumar, Vinod
Maroules, Michael
A Rare Case of Endocervical Adenocarcinoma of Gastric Type
title A Rare Case of Endocervical Adenocarcinoma of Gastric Type
title_full A Rare Case of Endocervical Adenocarcinoma of Gastric Type
title_fullStr A Rare Case of Endocervical Adenocarcinoma of Gastric Type
title_full_unstemmed A Rare Case of Endocervical Adenocarcinoma of Gastric Type
title_short A Rare Case of Endocervical Adenocarcinoma of Gastric Type
title_sort rare case of endocervical adenocarcinoma of gastric type
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882999/
https://www.ncbi.nlm.nih.gov/pubmed/36721594
http://dx.doi.org/10.7759/cureus.33059
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