A mechanism of uncompetitive inhibition of the serotonin transporter

The serotonin transporter (SERT/SLC6A4) is arguably the most extensively studied solute carrier (SLC). During its eponymous action – that is, the retrieval of serotonin from the extracellular space – SERT undergoes a conformational cycle. Typical inhibitors (antidepressant drugs and cocaine), partia...

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Detalles Bibliográficos
Autores principales: Bhat, Shreyas, El-Kasaby, Ali, Kasture, Ameya, Boytsov, Danila, Reichelt, Julian B, Hummel, Thomas, Sucic, Sonja, Pifl, Christian, Freissmuth, Michael, Sandtner, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883013/
https://www.ncbi.nlm.nih.gov/pubmed/36648438
http://dx.doi.org/10.7554/eLife.82641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883013/
https://www.ncbi.nlm.nih.gov/pubmed/36648438
http://dx.doi.org/10.7554/eLife.82641

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