Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 M(Pro) and PL(Pro)

In this paper, an environmentally benign, convenient, and efficient one-pot three-component reaction has been developed for the regioselective synthesis of novel 5-aroyl(or heteroaroyl)-6-(alkylamino)-1,3-dimethylfuro[2,3-d]pyrimidine-2,4(1H,3H)-diones (4a‒n) through the sequential condensation of a...

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Detalles Bibliográficos
Autores principales: Mousavi, Hossein, Zeynizadeh, Behzad, Rimaz, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883075/
https://www.ncbi.nlm.nih.gov/pubmed/37037129
http://dx.doi.org/10.1016/j.bioorg.2023.106390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883075/
https://www.ncbi.nlm.nih.gov/pubmed/37037129
http://dx.doi.org/10.1016/j.bioorg.2023.106390

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