Cargando…

The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults

OBJECTIVES: Helicobacter pylori (H. pylori) immunoglobulin G (IgG) seropositivity is prevalent, but its correlation with homocysteine (Hcy), a biomarker of vascular risk events, is unclear. This study is aimed at exploring the correlation of H. pylori IgG seropositivity and plasma Hcy levels in adul...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jinke, Yang, Xuefei, Zhang, Jiaqi, Wang, Fengyun, Tang, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883089/
https://www.ncbi.nlm.nih.gov/pubmed/36714243
http://dx.doi.org/10.1155/2023/7590549
_version_ 1784879430894616576
author Huang, Jinke
Yang, Xuefei
Zhang, Jiaqi
Wang, Fengyun
Tang, Xudong
author_facet Huang, Jinke
Yang, Xuefei
Zhang, Jiaqi
Wang, Fengyun
Tang, Xudong
author_sort Huang, Jinke
collection PubMed
description OBJECTIVES: Helicobacter pylori (H. pylori) immunoglobulin G (IgG) seropositivity is prevalent, but its correlation with homocysteine (Hcy), a biomarker of vascular risk events, is unclear. This study is aimed at exploring the correlation of H. pylori IgG seropositivity and plasma Hcy levels in adults. METHODS: Data was obtained from the National Health and Nutrition Examination Survey (NHANES) cycle 1999-2000. Hcy was measured by the Abbott homocysteine assay, and H. pylori IgG was measured by enzyme-linked immunosorbent assays. The weighted multiple logistic regression analyses with adjustments for potential confounders were conducted. Subgroup analyses stratified by gender, age, and race were performed. RESULTS: A total of 4029 subjects aged 20-85 years were included. Population prevalence of H. pylori IgG seropositivity was 44.7% in the overall population with higher prevalence found in those with older age, Mexican Americans, lower education, and lower household income. Levels of plasma Hcy were not elevated in those with H. pylori IgG seropositivity versus seronegativity (β -0.120 (-0.438, 0.199) P = 0.462). This difference was not significant after stratifying by gender and age. However, in the subgroup analyses stratified by race, a negative correlation between H. pylori seropositivity and plasma Hcy levels was observed in Mexican Americans (β -0.802 (-1.253, -0.352) P < 0.001). CONCLUSIONS: H. pylori IgG seropositivity was not associated with plasma Hcy levels in the general population, but there may be a negative correlation in Mexican Americans. These findings provide new insights to advance the research of the link between plasma Hcy levels and stomach health.
format Online
Article
Text
id pubmed-9883089
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-98830892023-01-28 The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults Huang, Jinke Yang, Xuefei Zhang, Jiaqi Wang, Fengyun Tang, Xudong Mediators Inflamm Research Article OBJECTIVES: Helicobacter pylori (H. pylori) immunoglobulin G (IgG) seropositivity is prevalent, but its correlation with homocysteine (Hcy), a biomarker of vascular risk events, is unclear. This study is aimed at exploring the correlation of H. pylori IgG seropositivity and plasma Hcy levels in adults. METHODS: Data was obtained from the National Health and Nutrition Examination Survey (NHANES) cycle 1999-2000. Hcy was measured by the Abbott homocysteine assay, and H. pylori IgG was measured by enzyme-linked immunosorbent assays. The weighted multiple logistic regression analyses with adjustments for potential confounders were conducted. Subgroup analyses stratified by gender, age, and race were performed. RESULTS: A total of 4029 subjects aged 20-85 years were included. Population prevalence of H. pylori IgG seropositivity was 44.7% in the overall population with higher prevalence found in those with older age, Mexican Americans, lower education, and lower household income. Levels of plasma Hcy were not elevated in those with H. pylori IgG seropositivity versus seronegativity (β -0.120 (-0.438, 0.199) P = 0.462). This difference was not significant after stratifying by gender and age. However, in the subgroup analyses stratified by race, a negative correlation between H. pylori seropositivity and plasma Hcy levels was observed in Mexican Americans (β -0.802 (-1.253, -0.352) P < 0.001). CONCLUSIONS: H. pylori IgG seropositivity was not associated with plasma Hcy levels in the general population, but there may be a negative correlation in Mexican Americans. These findings provide new insights to advance the research of the link between plasma Hcy levels and stomach health. Hindawi 2023-01-20 /pmc/articles/PMC9883089/ /pubmed/36714243 http://dx.doi.org/10.1155/2023/7590549 Text en Copyright © 2023 Jinke Huang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Jinke
Yang, Xuefei
Zhang, Jiaqi
Wang, Fengyun
Tang, Xudong
The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults
title The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults
title_full The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults
title_fullStr The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults
title_full_unstemmed The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults
title_short The Correlation between Helicobacter pylori Immunoglobulin G Seropositivity and Plasma Homocysteine Levels in Adults
title_sort correlation between helicobacter pylori immunoglobulin g seropositivity and plasma homocysteine levels in adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883089/
https://www.ncbi.nlm.nih.gov/pubmed/36714243
http://dx.doi.org/10.1155/2023/7590549
work_keys_str_mv AT huangjinke thecorrelationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT yangxuefei thecorrelationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT zhangjiaqi thecorrelationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT wangfengyun thecorrelationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT tangxudong thecorrelationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT huangjinke correlationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT yangxuefei correlationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT zhangjiaqi correlationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT wangfengyun correlationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults
AT tangxudong correlationbetweenhelicobacterpyloriimmunoglobulingseropositivityandplasmahomocysteinelevelsinadults