Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) is characterized by complex molecular alterations and driver mutations. Elderly patients show increased frequencies of IDH mutations with high chemoresistance and relapse rates despite recent therapeutic advances. Besides being associated with global promoter hypermethyl...

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Detalles Bibliográficos
Autores principales: Steinhäuser, Sophie, Silva, Patricia, Lenk, Lennart, Beder, Thomas, Hartmann, Alina, Hänzelmann, Sonja, Fransecky, Lars, Neumann, Martin, Bastian, Lorenz, Lipinski, Simone, Richter, Kathrin, Bultmann, Miriam, Hübner, Emely, Xia, Shuli, Röllig, Christoph, Vogiatzi, Fotini, Schewe, Denis Martin, Yumiceba, Veronica, Schultz, Kristin, Spielmann, Malte, Baldus, Claudia Dorothea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883162/
https://www.ncbi.nlm.nih.gov/pubmed/36411356
http://dx.doi.org/10.1038/s41375-022-01751-6

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