Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors

The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory and signaling levels. Recently, a long-tail hotspot mutation targeting the R-RAS2/TC21 Gln(72) residue (Q72L) was identified as a potent oncogenic driver...

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Detalles Bibliográficos
Autores principales: Clavaín, Laura, Fernández-Pisonero, Isabel, Movilla, Nieves, Lorenzo-Martín, L. Francisco, Nieto, Blanca, Abad, Antonio, García-Navas, Rósula, Llorente-González, Clara, Sánchez-Martín, Manuel, Vicente-Manzanares, Miguel, Santos, Eugenio, Alarcón, Balbino, García-Aznar, José M., Dosil, Mercedes, Bustelo, Xosé R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883167/
https://www.ncbi.nlm.nih.gov/pubmed/36476833
http://dx.doi.org/10.1038/s41388-022-02563-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883167/
https://www.ncbi.nlm.nih.gov/pubmed/36476833
http://dx.doi.org/10.1038/s41388-022-02563-9

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