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Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors
The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory and signaling levels. Recently, a long-tail hotspot mutation targeting the R-RAS2/TC21 Gln(72) residue (Q72L) was identified as a potent oncogenic driver...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883167/ https://www.ncbi.nlm.nih.gov/pubmed/36476833 http://dx.doi.org/10.1038/s41388-022-02563-9 |