Deep-learning based approach to identify substrates of human E3 ubiquitin ligases and deubiquitinases

E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) play key roles in protein degradation. However, a large number of E3 substrate interactions (ESIs) and DUB substrate interactions (DSIs) remain elusive. Here, we present DeepUSI, a deep learning-based framework to identify ESIs and DSIs...

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Detalles Bibliográficos
Autores principales: Shu, Yixuan, Hai, Yanru, Cao, Lihua, Wu, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883182/
https://www.ncbi.nlm.nih.gov/pubmed/36733699
http://dx.doi.org/10.1016/j.csbj.2023.01.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883182/
https://www.ncbi.nlm.nih.gov/pubmed/36733699
http://dx.doi.org/10.1016/j.csbj.2023.01.021

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