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Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is an important factor in the integrated stress response (ISR) in mammals and may play a crucial role in tumorigenesis. In our studies, we found an inhibitor of PPP1R15A, Sephin1, plays a protumorigenic role in mouse tumor models. By analyzing...

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Detalles Bibliográficos
Autores principales:	Wang, Rongjing, Zhang, Yuchao, Guo, Shiwei, Pei, Siyu, Guo, Wei, Wu, Zhenchuan, Wang, Hailong, Wang, Minghui, Li, Yizhe, Zhu, Yufei, Meng, Ling-Hua, Lang, Jingyu, Jin, Gang, Xiao, Yichuan, Hu, Landian, Kong, Xiangyin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883195/ https://www.ncbi.nlm.nih.gov/pubmed/36718369 http://dx.doi.org/10.1016/j.isci.2023.105954

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