Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration

Drosophila Toll-9 is most closely related to mammalian Toll-like receptors; however, physiological functions of Toll-9 remain elusive. We examined the roles of Toll-9 in fly brains in aging and neurodegeneration. Toll-9 mRNA levels were increased in aged fly heads accompanied by activation of nuclea...

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Detalles Bibliográficos
Autores principales: Sakakibara, Yasufumi, Yamashiro, Risa, Chikamatsu, Sachie, Hirota, Yu, Tsubokawa, Yoko, Nishijima, Risa, Takei, Kimi, Sekiya, Michiko, Iijima, Koichi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883205/
https://www.ncbi.nlm.nih.gov/pubmed/36718365
http://dx.doi.org/10.1016/j.isci.2023.105968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883205/
https://www.ncbi.nlm.nih.gov/pubmed/36718365
http://dx.doi.org/10.1016/j.isci.2023.105968

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