Cargando…

Deep learning-based hemorrhage detection for diabetic retinopathy screening

Diabetic retinopathy is a retinal compilation that causes visual impairment. Hemorrhage is one of the pathological symptoms of diabetic retinopathy that emerges during disease development. Therefore, hemorrhage detection reveals the presence of diabetic retinopathy in the early phase. Diagnosing the...

Descripción completa

Detalles Bibliográficos
Autores principales: Aziz, Tamoor, Charoenlarpnopparut, Chalie, Mahapakulchai, Srijidtra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883230/
https://www.ncbi.nlm.nih.gov/pubmed/36707608
http://dx.doi.org/10.1038/s41598-023-28680-3
_version_ 1784879463592361984
author Aziz, Tamoor
Charoenlarpnopparut, Chalie
Mahapakulchai, Srijidtra
author_facet Aziz, Tamoor
Charoenlarpnopparut, Chalie
Mahapakulchai, Srijidtra
author_sort Aziz, Tamoor
collection PubMed
description Diabetic retinopathy is a retinal compilation that causes visual impairment. Hemorrhage is one of the pathological symptoms of diabetic retinopathy that emerges during disease development. Therefore, hemorrhage detection reveals the presence of diabetic retinopathy in the early phase. Diagnosing the disease in its initial stage is crucial to adopt proper treatment so the repercussions can be prevented. The automatic deep learning-based hemorrhage detection method is proposed that can be used as the second interpreter for ophthalmologists to reduce the time and complexity of conventional screening methods. The quality of the images was enhanced, and the prospective hemorrhage locations were estimated in the preprocessing stage. Modified gamma correction adaptively illuminates fundus images by using gradient information to address the nonuniform brightness levels of images. The algorithm estimated the locations of potential candidates by using a Gaussian match filter, entropy thresholding, and mathematical morphology. The required objects were segmented using the regional diversity at estimated locations. The novel hemorrhage network is propounded for hemorrhage classification and compared with the renowned deep models. Two datasets benchmarked the model’s performance using sensitivity, specificity, precision, and accuracy metrics. Despite being the shallowest network, the proposed network marked competitive results than LeNet-5, AlexNet, ResNet50, and VGG-16. The hemorrhage network was assessed using training time and classification accuracy through synthetic experimentation. Results showed promising accuracy in the classification stage while significantly reducing training time. The research concluded that increasing deep network layers does not guarantee good results but rather increases training time. The suitable architecture of a deep model and its appropriate parameters are critical for obtaining excellent outcomes.
format Online
Article
Text
id pubmed-9883230
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-98832302023-01-29 Deep learning-based hemorrhage detection for diabetic retinopathy screening Aziz, Tamoor Charoenlarpnopparut, Chalie Mahapakulchai, Srijidtra Sci Rep Article Diabetic retinopathy is a retinal compilation that causes visual impairment. Hemorrhage is one of the pathological symptoms of diabetic retinopathy that emerges during disease development. Therefore, hemorrhage detection reveals the presence of diabetic retinopathy in the early phase. Diagnosing the disease in its initial stage is crucial to adopt proper treatment so the repercussions can be prevented. The automatic deep learning-based hemorrhage detection method is proposed that can be used as the second interpreter for ophthalmologists to reduce the time and complexity of conventional screening methods. The quality of the images was enhanced, and the prospective hemorrhage locations were estimated in the preprocessing stage. Modified gamma correction adaptively illuminates fundus images by using gradient information to address the nonuniform brightness levels of images. The algorithm estimated the locations of potential candidates by using a Gaussian match filter, entropy thresholding, and mathematical morphology. The required objects were segmented using the regional diversity at estimated locations. The novel hemorrhage network is propounded for hemorrhage classification and compared with the renowned deep models. Two datasets benchmarked the model’s performance using sensitivity, specificity, precision, and accuracy metrics. Despite being the shallowest network, the proposed network marked competitive results than LeNet-5, AlexNet, ResNet50, and VGG-16. The hemorrhage network was assessed using training time and classification accuracy through synthetic experimentation. Results showed promising accuracy in the classification stage while significantly reducing training time. The research concluded that increasing deep network layers does not guarantee good results but rather increases training time. The suitable architecture of a deep model and its appropriate parameters are critical for obtaining excellent outcomes. Nature Publishing Group UK 2023-01-27 /pmc/articles/PMC9883230/ /pubmed/36707608 http://dx.doi.org/10.1038/s41598-023-28680-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Aziz, Tamoor
Charoenlarpnopparut, Chalie
Mahapakulchai, Srijidtra
Deep learning-based hemorrhage detection for diabetic retinopathy screening
title Deep learning-based hemorrhage detection for diabetic retinopathy screening
title_full Deep learning-based hemorrhage detection for diabetic retinopathy screening
title_fullStr Deep learning-based hemorrhage detection for diabetic retinopathy screening
title_full_unstemmed Deep learning-based hemorrhage detection for diabetic retinopathy screening
title_short Deep learning-based hemorrhage detection for diabetic retinopathy screening
title_sort deep learning-based hemorrhage detection for diabetic retinopathy screening
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883230/
https://www.ncbi.nlm.nih.gov/pubmed/36707608
http://dx.doi.org/10.1038/s41598-023-28680-3
work_keys_str_mv AT aziztamoor deeplearningbasedhemorrhagedetectionfordiabeticretinopathyscreening
AT charoenlarpnopparutchalie deeplearningbasedhemorrhagedetectionfordiabeticretinopathyscreening
AT mahapakulchaisrijidtra deeplearningbasedhemorrhagedetectionfordiabeticretinopathyscreening