USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

Ubiquitin-specific protease 39(USP39) plays an important role in modulating pre-mRNA splicing and ubiquitin-proteasome dependent proteolysis as a member of conserved deubiquitylation family. Accumulating evidences prove that USP39 participates in the development of hepatocellular carcinoma (HCC). Ho...

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Detalles Bibliográficos
Autores principales: Wang, Weiwei, Lei, Yongbin, Zhang, Gongye, Li, Xiaomei, Yuan, Jiahui, Li, Tingting, Zhong, Wei, Zhang, Yuqi, Tan, Xuemei, Song, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883245/
https://www.ncbi.nlm.nih.gov/pubmed/36707504
http://dx.doi.org/10.1038/s41419-023-05593-7

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