Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum

Malaria eradication requires the development of new drugs to combat drug-resistant parasites. We identified bisbenzylisoquinoline alkaloids isolated from Cocculus hirsutus that are active against Plasmodium falciparum blood stages. Synthesis of a library of 94 hemi-synthetic derivatives allowed to i...

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Detalles Bibliográficos
Autores principales: Nardella, Flore, Dobrescu, Irina, Hassan, Haitham, Rodrigues, Fabien, Thiberge, Sabine, Mancio-Silva, Liliana, Tafit, Ambre, Jallet, Corinne, Cadet-Daniel, Véronique, Goussin, Stéphane, Lorthiois, Audrey, Menon, Yoann, Molinier, Nicolas, Pechalrieu, Dany, Long, Christophe, Sautel, François, Matondo, Mariette, Duchateau, Magalie, Médard, Guillaume, Witkowski, Benoit, Scherf, Artur, Halby, Ludovic, Arimondo, Paola B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883252/
https://www.ncbi.nlm.nih.gov/pubmed/36718363
http://dx.doi.org/10.1016/j.isci.2023.105940

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