MDM2 antagonists promote CRISPR/Cas9-mediated precise genome editing in sheep primary cells

CRISPR-Cas9-mediated genome editing in sheep is of great use in both agricultural and biomedical applications. While targeted gene knockout by CRISPR-Cas9 through non-homologous end joining (NHEJ) has worked efficiently, the knockin efficiency via homology-directed repair (HDR) remains lower, which...

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Detalles Bibliográficos
Autores principales: Li, Yan, Lian, Di, Wang, Jiahao, Zhao, Yue, Li, Yao, Liu, Guoshi, Wu, Sen, Deng, Shoulong, Du, Xuguang, Lian, Zhengxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883270/
https://www.ncbi.nlm.nih.gov/pubmed/36726409
http://dx.doi.org/10.1016/j.omtn.2022.12.020

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