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The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis

BACKGROUND & AIMS: Fibrosis is a common complication of inflammatory bowel diseases (IBDs). The pregnane X receptor (PXR) (encoded by NR1I2) suppresses intestinal inflammation and has been shown to influence liver fibrosis. In the intestine, PXR signaling is influenced by microbiota-derived indo...

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Detalles Bibliográficos
Autores principales:	Flannigan, Kyle L., Nieves, Kristoff M., Szczepanski, Holly E., Serra, Alex, Lee, Joshua W., Alston, Laurie A., Ramay, Hena, Mani, Sridhar, Hirota, Simon A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883297/ https://www.ncbi.nlm.nih.gov/pubmed/36309199 http://dx.doi.org/10.1016/j.jcmgh.2022.10.014

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