Cargando…
CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis
PURPOSE: Due to the high morbidity and mortality of infective endocarditis (IE), medical imaging techniques are combined to ensure a correct diagnosis. [(18)F]FDG PET/CT has demonstrated the ability to improve diagnostic accuracy compared with the conventional modified Duke criteria in patients with...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883360/ https://www.ncbi.nlm.nih.gov/pubmed/36053441 http://dx.doi.org/10.1007/s11548-022-02729-6 |
_version_ | 1784879492105240576 |
---|---|
author | Palomino-Fernández, David Gómez-Grande, Adolfo Fernández-Igarza, Mirene Pilkington, Patrick Seiffert, Alexander P. Bueno, Héctor Gómez, Enrique J. Sánchez-González, Patricia |
author_facet | Palomino-Fernández, David Gómez-Grande, Adolfo Fernández-Igarza, Mirene Pilkington, Patrick Seiffert, Alexander P. Bueno, Héctor Gómez, Enrique J. Sánchez-González, Patricia |
author_sort | Palomino-Fernández, David |
collection | PubMed |
description | PURPOSE: Due to the high morbidity and mortality of infective endocarditis (IE), medical imaging techniques are combined to ensure a correct diagnosis. [(18)F]FDG PET/CT has demonstrated the ability to improve diagnostic accuracy compared with the conventional modified Duke criteria in patients with suspected IE, especially those with prosthetic valve infective endocarditis (PVIE). The aim of this study is to provide an adjunctive diagnostic tool to improve the diagnostic accuracy in cardiovascular infections, specifically PVIE. METHODS: A segmentation tool to extract quantitative measures of [(18)F]FDG PET/CT image studies of prosthetic heart valve regions was developed and validated in 20 cases of suspected PVIE, of which 9 were confirmed. For that, Valvular Heterogeneity Index (VHI) and Ring-to-Center Ratio (RCR) were defined. RESULTS: Results show an overall increase in the metabolic uptake of the prosthetic valve ring in the studies with confirmed PVIE diagnosis (SUV(max) from 1.70 to 3.20; SUV(mean) from 0.86 to 1.50). The VHI and RCR showed areas under the curve of 0.727 and 0.808 in the receiver operating characteristics curve analyses, respectively, for PVIE diagnosis. Mann–Whitney U tests showed statistically significant differences between groups for RCR (p = 0.02). Visual analyses and clinical reports were concordant with the extracted quantitative metrics. CONCLUSION: The proposed new method and presented software solution (CASSIA) provide the capability to assess quantitatively myocardial metabolism along the prosthetic valve region in routine [(18)F]FDG PET/CT scans for evaluating heart valve infectious processes. VHI and RCR are proposed as new potential adjunctive measures for PVIE diagnosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11548-022-02729-6. |
format | Online Article Text |
id | pubmed-9883360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-98833602023-01-29 CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis Palomino-Fernández, David Gómez-Grande, Adolfo Fernández-Igarza, Mirene Pilkington, Patrick Seiffert, Alexander P. Bueno, Héctor Gómez, Enrique J. Sánchez-González, Patricia Int J Comput Assist Radiol Surg Original Article PURPOSE: Due to the high morbidity and mortality of infective endocarditis (IE), medical imaging techniques are combined to ensure a correct diagnosis. [(18)F]FDG PET/CT has demonstrated the ability to improve diagnostic accuracy compared with the conventional modified Duke criteria in patients with suspected IE, especially those with prosthetic valve infective endocarditis (PVIE). The aim of this study is to provide an adjunctive diagnostic tool to improve the diagnostic accuracy in cardiovascular infections, specifically PVIE. METHODS: A segmentation tool to extract quantitative measures of [(18)F]FDG PET/CT image studies of prosthetic heart valve regions was developed and validated in 20 cases of suspected PVIE, of which 9 were confirmed. For that, Valvular Heterogeneity Index (VHI) and Ring-to-Center Ratio (RCR) were defined. RESULTS: Results show an overall increase in the metabolic uptake of the prosthetic valve ring in the studies with confirmed PVIE diagnosis (SUV(max) from 1.70 to 3.20; SUV(mean) from 0.86 to 1.50). The VHI and RCR showed areas under the curve of 0.727 and 0.808 in the receiver operating characteristics curve analyses, respectively, for PVIE diagnosis. Mann–Whitney U tests showed statistically significant differences between groups for RCR (p = 0.02). Visual analyses and clinical reports were concordant with the extracted quantitative metrics. CONCLUSION: The proposed new method and presented software solution (CASSIA) provide the capability to assess quantitatively myocardial metabolism along the prosthetic valve region in routine [(18)F]FDG PET/CT scans for evaluating heart valve infectious processes. VHI and RCR are proposed as new potential adjunctive measures for PVIE diagnosis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11548-022-02729-6. Springer International Publishing 2022-09-02 2023 /pmc/articles/PMC9883360/ /pubmed/36053441 http://dx.doi.org/10.1007/s11548-022-02729-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Palomino-Fernández, David Gómez-Grande, Adolfo Fernández-Igarza, Mirene Pilkington, Patrick Seiffert, Alexander P. Bueno, Héctor Gómez, Enrique J. Sánchez-González, Patricia CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis |
title | CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis |
title_full | CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis |
title_fullStr | CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis |
title_full_unstemmed | CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis |
title_short | CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)F]FDG PET/CT in the setting of infective endocarditis |
title_sort | cassia (cardiology software suite for image analysis): a potential new tool for the evaluation of [(18)f]fdg pet/ct in the setting of infective endocarditis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883360/ https://www.ncbi.nlm.nih.gov/pubmed/36053441 http://dx.doi.org/10.1007/s11548-022-02729-6 |
work_keys_str_mv | AT palominofernandezdavid cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT gomezgrandeadolfo cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT fernandezigarzamirene cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT pilkingtonpatrick cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT seiffertalexanderp cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT buenohector cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT gomezenriquej cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis AT sanchezgonzalezpatricia cassiacardiologysoftwaresuiteforimageanalysisapotentialnewtoolfortheevaluationof18ffdgpetctinthesettingofinfectiveendocarditis |