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Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer
BACKGROUND: The wide applicability of the Naples prognostic score (NPS) is still worthy of further study in gastric cancer (GC). This study aimed to construct a New‐NPS based on the differences in immunity and nutrition in patients with upper and lower gastrointestinal tumors to help obtain an indiv...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883407/ https://www.ncbi.nlm.nih.gov/pubmed/35833662 http://dx.doi.org/10.1002/cam4.5017 |
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author | Wang, Hao Fang, Tianyi Yin, Xin Lou, Shenghan Han, Bangling Gao, Jialiang Wang, Yufei Wang, Xibo Zhang, Daoxu Wang, Yimin Zhang, Yao Xue, Yingwei |
author_facet | Wang, Hao Fang, Tianyi Yin, Xin Lou, Shenghan Han, Bangling Gao, Jialiang Wang, Yufei Wang, Xibo Zhang, Daoxu Wang, Yimin Zhang, Yao Xue, Yingwei |
author_sort | Wang, Hao |
collection | PubMed |
description | BACKGROUND: The wide applicability of the Naples prognostic score (NPS) is still worthy of further study in gastric cancer (GC). This study aimed to construct a New‐NPS based on the differences in immunity and nutrition in patients with upper and lower gastrointestinal tumors to help obtain an individualized prediction of prognosis. METHODS: This study retrospectively analyzed patients who underwent radical gastrectomy from April 2014 to September 2016. The cutoff values of the preoperative neutrophil‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte ratio (LMR), serum albumin (Alb), and total cholesterol (TC) were calculated by ROC curve analysis. ROC and t‐ROC were used to evaluate the accuracy of the prognostic markers. The Kaplan–Meier method and log‐rank test were used to analyze the overall survival probability. Univariate and multivariate analyses based on Cox risk regression were used to show the independent predictors. The nomogram was made by R studio. The predictive accuracy of nomogram was assessed using a calibration plot, concordance index (C‐index), and decision curve. RESULTS: A total of 737 patients were included in training cohort, 411 patients were included in validation cohort. ROC showed that the New‐NPS was more suitable for predicting the prognosis of GC patients. NPS = 2 indicated a poor prognosis. Multivariate analysis showed that CEA (P = 0.026), Borrmann type (P = 0.001), pTNM (P < 0.001), New‐NPS (P < 0.001), and nerve infiltration (P = 0.035) were independent risk factors for prognosis. CONCLUSION: The New‐NPS based on the cutoff values of NLR, LMR, Alb, and TC is not only suitable for predicting prognosis but can also be combined with clinicopathological characteristics to construct a nomogram model for GC patients. |
format | Online Article Text |
id | pubmed-9883407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98834072023-01-30 Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer Wang, Hao Fang, Tianyi Yin, Xin Lou, Shenghan Han, Bangling Gao, Jialiang Wang, Yufei Wang, Xibo Zhang, Daoxu Wang, Yimin Zhang, Yao Xue, Yingwei Cancer Med RESEARCH ARTICLES BACKGROUND: The wide applicability of the Naples prognostic score (NPS) is still worthy of further study in gastric cancer (GC). This study aimed to construct a New‐NPS based on the differences in immunity and nutrition in patients with upper and lower gastrointestinal tumors to help obtain an individualized prediction of prognosis. METHODS: This study retrospectively analyzed patients who underwent radical gastrectomy from April 2014 to September 2016. The cutoff values of the preoperative neutrophil‐to‐lymphocyte ratio (NLR), lymphocyte‐to‐monocyte ratio (LMR), serum albumin (Alb), and total cholesterol (TC) were calculated by ROC curve analysis. ROC and t‐ROC were used to evaluate the accuracy of the prognostic markers. The Kaplan–Meier method and log‐rank test were used to analyze the overall survival probability. Univariate and multivariate analyses based on Cox risk regression were used to show the independent predictors. The nomogram was made by R studio. The predictive accuracy of nomogram was assessed using a calibration plot, concordance index (C‐index), and decision curve. RESULTS: A total of 737 patients were included in training cohort, 411 patients were included in validation cohort. ROC showed that the New‐NPS was more suitable for predicting the prognosis of GC patients. NPS = 2 indicated a poor prognosis. Multivariate analysis showed that CEA (P = 0.026), Borrmann type (P = 0.001), pTNM (P < 0.001), New‐NPS (P < 0.001), and nerve infiltration (P = 0.035) were independent risk factors for prognosis. CONCLUSION: The New‐NPS based on the cutoff values of NLR, LMR, Alb, and TC is not only suitable for predicting prognosis but can also be combined with clinicopathological characteristics to construct a nomogram model for GC patients. John Wiley and Sons Inc. 2022-07-14 /pmc/articles/PMC9883407/ /pubmed/35833662 http://dx.doi.org/10.1002/cam4.5017 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RESEARCH ARTICLES Wang, Hao Fang, Tianyi Yin, Xin Lou, Shenghan Han, Bangling Gao, Jialiang Wang, Yufei Wang, Xibo Zhang, Daoxu Wang, Yimin Zhang, Yao Xue, Yingwei Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer |
title | Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer |
title_full | Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer |
title_fullStr | Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer |
title_full_unstemmed | Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer |
title_short | Prognostic importance of the preoperative New‐Naples prognostic score for patients with gastric cancer |
title_sort | prognostic importance of the preoperative new‐naples prognostic score for patients with gastric cancer |
topic | RESEARCH ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883407/ https://www.ncbi.nlm.nih.gov/pubmed/35833662 http://dx.doi.org/10.1002/cam4.5017 |
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