Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate

Neural stem cell (NSC) maintenance and functions are regulated by reactive oxygen species (ROS). However, the mechanisms by which ROS control NSC behavior remain unclear. Here we report that ROS-dependent Igfbp2 signaling controls DNA repair pathways which balance NSC self-renewal and lineage commit...

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Detalles Bibliográficos
Autores principales: Shahin, Weam S., Ebed, Shima O., Tyler, Scott R., Miljkovic, Branko, Choi, Soon H., Zhang, Yulong, Zhou, Weihong, Evans, Idil A., Yeaman, Charles, Engelhardt, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883463/
https://www.ncbi.nlm.nih.gov/pubmed/36707536
http://dx.doi.org/10.1038/s41467-023-36174-z

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