Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production

Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry. In previous studies, we observed strong correlations between the performance of CHO cells and expression of two transcri...

Descripción completa

Detalles Bibliográficos
Autores principales: Latorre, Yesenia, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Sampayo, Maria Molina, Gödecke, Natasha, Wirth, Dagmar, Hauser, Hansjörg, Dickson, Alan J., Altamirano, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883479/
https://www.ncbi.nlm.nih.gov/pubmed/36707606
http://dx.doi.org/10.1038/s41598-023-28622-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883479/
https://www.ncbi.nlm.nih.gov/pubmed/36707606
http://dx.doi.org/10.1038/s41598-023-28622-z

Ejemplares similares