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Engineering of Chinese hamster ovary cells for co-overexpressing MYC and XBP1s increased cell proliferation and recombinant EPO production

Improving the cellular capacity of Chinese hamster ovary (CHO) cells to produce large amounts of therapeutic proteins remains a major challenge for the biopharmaceutical industry. In previous studies, we observed strong correlations between the performance of CHO cells and expression of two transcri...

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Detalles Bibliográficos
Autores principales:	Latorre, Yesenia, Torres, Mauro, Vergara, Mauricio, Berrios, Julio, Sampayo, Maria Molina, Gödecke, Natasha, Wirth, Dagmar, Hauser, Hansjörg, Dickson, Alan J., Altamirano, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9883479/ https://www.ncbi.nlm.nih.gov/pubmed/36707606 http://dx.doi.org/10.1038/s41598-023-28622-z

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